منابع مشابه
The p53/p63/p73 family
The p53 gene is a tumor suppressor gene and the most frequent site of genetic alterations found in human cancers (Hollstein et al., 1991, 1996). Transgenic mice expressing mutant p53 or p53−/− mice are very prone to both spontaneous and induced tumors (Donehower et al., 1992). The p53 protein is a sequencespecific transcription factor that regulates the expression of genes involved in cell cycl...
متن کاملp53/p63/p73 in the epidermis in health and disease.
Although p53 has long been known as the "guardian of the genome" with a role in tumor suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more than a decade ago has triggered a considerable amount of research into the role of these genes in skin development and diseases. In this review, we primarily focus on mechanisms of action of p53 and p63, which are the best...
متن کاملp63 and p73: roles in development and tumor formation.
The tumor suppressor p53 is critically important in the cellular damage response and is the founding member of a family of proteins. All three genes regulate cell cycle and apoptosis after DNA damage. However, despite a remarkable structural and partly functional similarity among p53, p63, and p73, mouse knockout studies revealed an unexpected functional diversity among them. p63 and p73 knocko...
متن کاملPhylogenetic Analysis of the p53 and p63/p73 Gene Families
Proteins of the relative families p53 and p63/p73 are transcriptional factors that are involved in the signaling pathway in cells. The wide spectrum of their functions includes cell cycle arrest and apoptosis in response to DNA damage. The p53 protein also participates in development of particular tissues during embryogenesis. Thus, it is of high importance to establish the relation between str...
متن کاملp63 and p73 Transcriptionally Regulate Genes Involved in DNA Repair
The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that they activate a unique transcriptional network. Therefore, we performed a genome-wide analysis using cells lacking the p53 family members after treatment with DNA damage. We ide...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.9.15383